LymphedemaV1, Main, Exploration, bibRecord, 012D97

Differential humoral and cellular immunoreactivity to saline- and detergent-extracted filarial antigens.

Identifieur interne : 012D97 ( Main/Exploration ); précédent : 012D96; suivant : 012D98

Differential humoral and cellular immunoreactivity to saline- and detergent-extracted filarial antigens.

Auteurs : P J Lammie [États-Unis] ; M L Eberhard ; R C Lowrie

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]

RBID : pubmed:2260176

Descripteurs français

KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (biosynthèse), Antigènes d'helminthe (immunologie), Brugia (immunologie), Détergents, Enfant, Filariose lymphatique (immunologie), Humains, Immunité cellulaire, Wuchereria bancrofti (immunologie), Électrophorèse sur gel de polyacrylamide.
MESH :
- biosynthèse : Anticorps antihelminthe.
- immunologie : Antigènes d'helminthe, Brugia, Filariose lymphatique, Wuchereria bancrofti.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Détergents, Enfant, Humains, Immunité cellulaire, Électrophorèse sur gel de polyacrylamide.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Antibodies, Helminth (biosynthesis), Antigens, Helminth (immunology), Brugia (immunology), Child, Detergents, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Humans, Immunity, Cellular, Lymphocyte Activation, Middle Aged, Wuchereria bancrofti (immunology).
MESH :
- chemical , biosynthesis : Antibodies, Helminth.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Wuchereria bancrofti.
- Adolescent, Adult, Animals, Child, Detergents, Electrophoresis, Polyacrylamide Gel, Humans, Immunity, Cellular, Lymphocyte Activation, Middle Aged.

Abstract

The immunoreactivity to saline- and detergent-extracted filarial antigens of 31 Haitian subjects exposed to or infected with Wuchereria bancrofti was analysed. Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/amicrofilaraemic groups of patients. These patterns of immunoreactivity may reflect intrinsic differences between the 2 antigenic preparations in terms of composition or their mode of presentation to the host immune system.

PubMed: 2260176

Affiliations:

Le document en format XML

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<author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Antibodies, Helminth (biosynthesis)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Brugia (immunology)</term>
<term>Child</term>
<term>Detergents</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
<term>Lymphocyte Activation</term>
<term>Middle Aged</term>
<term>Wuchereria bancrofti (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Anticorps antihelminthe (biosynthèse)</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Brugia (immunologie)</term>
<term>Détergents</term>
<term>Enfant</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Humains</term>
<term>Immunité cellulaire</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Brugia</term>
<term>Filariose lymphatique</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term>
<term>Elephantiasis, Filarial</term>
<term>Wuchereria bancrofti</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Child</term>
<term>Detergents</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Humans</term>
<term>Immunity, Cellular</term>
<term>Lymphocyte Activation</term>
<term>Middle Aged</term>
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<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Détergents</term>
<term>Enfant</term>
<term>Humains</term>
<term>Immunité cellulaire</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
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<front><div type="abstract" xml:lang="en">The immunoreactivity to saline- and detergent-extracted filarial antigens of 31 Haitian subjects exposed to or infected with Wuchereria bancrofti was analysed. Cellular reactivity, monitored by blastogenesis in vitro, was significantly greater to a soluble extract of Brugia pahangi than to a detergent-extracted antigenic preparation. In contrast, serum antibody levels against the detergent extract were significantly higher. These differences were consistently observed in symptomatic, microfilaraemic, and asymptomatic/amicrofilaraemic groups of patients. These patterns of immunoreactivity may reflect intrinsic differences between the 2 antigenic preparations in terms of composition or their mode of presentation to the host immune system.</div>
</front>
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<name sortKey="Lowrie, R C" sort="Lowrie, R C" uniqKey="Lowrie R" first="R C" last="Lowrie">R C Lowrie</name>
</noCountry>
<country name="États-Unis"><region name="Louisiane"><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name>
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Differential humoral and cellular immunoreactivity to saline- and detergent-extracted filarial antigens.

Differential humoral and cellular immunoreactivity to saline- and detergent-extracted filarial antigens.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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